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Originally opened in August of 1967, the Adventure Thru Inner Space closed permanently in 1985, to make room for Star Tours. As a tribute to the former Tomorrowland attraction, the Monsanto Mighty Microscope appears during the Starspeeder's flight through the restricted maintenance hangar. The apparatus that shrank ATIS adventurers, the Monsanto Mighty Microscope was originally located in the attraction lobby, near where R2-D2 and the Starspeeder are located.

Star Tours was temporarily closed on July 27, 2010, the attraction is scheduled to re-open in May 2011, as Star Tours - The Adventures Continue.